Total Sleep Time and Other Sleep Characteristics Measured by Actigraphy Do Not Predict Incident Hypertension in a Cohort of Community-Dwelling Older Men
1San Diego Veterans Affairs Healthcare System, Medicine Service La Jolla, CA; 2University of California, San Diego, Department of Medicine, San Diego, CA; 3San Francisco Coordinating Center and California Pacific Medical Center Research Institute, San Francisco, CA; 4University of California, San Diego, Department of Psychiatry, San Diego, CA; 5Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Department of Medicine, Boston, MA; 6University of California, San Diego, Department of Family and Preventive Medicine, San Diego, CA
To evaluate whether actigraphy-measured total sleep time and other sleep characteristics predict incident hypertension in older men.
Study subjects were community-dwelling participants in the ancillary sleep study of the Osteoporotic Fractures in Men Study (MrOS) who were normotensive at the time of actigraphy (based on self-report, lack of antihypertensive medication use, and with systolic blood pressure < 140 mm Hg and diastolic blood pressure < 90 mm Hg). In 853 community-dwelling men 67 years and older (mean 75.1 years), sleep measures (total sleep time [TST]), percent sleep [%-sleep], latency, and wake after sleep onset [WASO]) were obtained using validated wrist actigraphy with data collected over a mean duration of 5.2 consecutive 24-h periods. We evaluated incident hypertension (based on self-report, use of antihypertensive medication, or measured systolic blood pressure ≥ 140 mm Hg or diastolic blood pressure ≥ 90 mm Hg) at a follow-up visit an average of 3.4 years later. Baseline prehypertension was defined as a systolic blood pressure 120 to < 140 mm Hg or diastolic blood pressure 80 to < 90 mm Hg.
At follow-up, 31% of initially normotensive men were hypertensive (264 of 853). Those with incident hypertension had higher baseline body mass index (BMI; kg/m2) and were more likely to have had prehypertension at the sleep visit than those men who remained normotensive. However, neither TST (reference 6 to < 8 h; < 6 h OR 0.96 [95% CI 0.7, 1.3] and ≥ 8 h OR 0.93 [0.5, 1.7]) nor the other actigraphic-measured sleep variables, including % -sleep (reference > 85%; < 70% OR 1.17 [0.66, 2.08]) and 70% to ≤ 85% OR 1.23 (0.9, 1.68), sleep latency (reference < 30 min; ≥ 30 min OR 1.29 [0.94, 1.76]), or WASO (reference < 30 min; 30 to < 60 min OR 0.7 [0.43, 1.14] and ≥ 60 min OR 0.92 [0.58, 1.47]) differed in those community-dwelling men who developed incident hypertension compared to those who remained normotensive.
TST and other sleep parameters determined by wrist actigraphy were not associated with incident hypertension in community-dwelling older men.
Fung MM; Peters K; Ancoli-Israel S; Redline S; Stone KL; Barrett-Connor E. Total sleep time and other sleep characteristics measured by actigraphy do not predict incident hypertension in a cohort of community-dwelling older men. J Clin Sleep Med 2013;9(6):585-591.
Please login to continue reading the full article
Subscribers to JCSM get full access to current and past issues of the JCSM.
Login to JCSM
Not a subscriber?
Join the American Academy of Sleep Medicine and receive a subscription to JCSM with your membership