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Volume 09 No. 11
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Accepted Papers

Case Reports

Kleine-Levin Syndrome Treated With Clarithromycin

Elham Rezvanian, M.D.1,2; Nathaniel F. Watson, M.D., M.Sc., F.A.A.S.M.1,3
1University of Washington Medicine Sleep Center; 2Department of Medicine, Division of Pulmonary and Critical Care, University of Washington; 3Department of Neurology, University of Washington, Seattle, WA

Kleine-Levin syndrome (KLS) is a rare sleep disorder characterized by periodic hypersomnia and various degrees of cognitive and behavioral disturbance, hyperphagia, and hypersexuality. Effective treatment is challenging. Stimulants marginally address sleepiness, but may increase irritability and do not improve cognitive and behavioral disturbances. Modafinil may shorten the symptomatic period but not the recurrence rate. Lithium and carbamazepine are beneficial in some cases, possibly related to similarities between KLS and affective disorders. Currently, no single medication is consistently successful in treating the syndrome. Here we report the short-term effect of clarithromycin in a patient with KLS.


Rezvanian E; Watson NF. Kleine-Levin syndrome treated with clarithromycin. J Clin Sleep Med 2013;9(11):1211-1212.

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