A new review of the scientific literature by the National Academies of Sciences, Engineering, and Medicine describes the Health Effects of Cannabis and Cannabinoids, including its effects on sleep and potential therapeutic benefits for sleep disorders. The report concludes that there is moderate evidence that cannabis or cannabinoids are effective for improving short-term sleep outcomes in individuals with sleep disturbance associated with obstructive sleep apnea, fibromyalgia, chronic pain, and multiple sclerosis (cannabinoids, primarily nabiximols).

The report also noted the identification of a distinctive marijuana withdrawal syndrome, which is mild and short-lived. The syndrome includes restlessness, irritability, mild agitation, insomnia, sleep disturbance, nausea, and cramping.