Disconnection between Periodic Leg Movements and Cortical Arousals in Spinal Cord Injury
1University of Tampere, School of Medicine, Tampere, Finland; 2Unesta Research Centre, Tampere, Finland; 3Sleep and Epilepsy Center, Neurocenter of the Southern Switzerland, Civic Hospital of Lugano, Lugano, Switzerland; 4Department of Neurosciences and Rehabilitation, Tampere University Hospital, Tampere, Finland; 5Sleep Research Centre, Department of Neurology IC, Oasi Research Institute (IRCCS), Troina, Italy; 6Department of Respiratory Medicine, Tampere University Hospital, Tampere, Finland
In this study we examine the temporal connection between periodic leg movements (PLMs) and cortical arousals, as well as the treatment effect of pramipexole, in a clinical case with spinal cord lesion.
A patient with complete cervical spinal cord injury and PLMs during sleep underwent two baseline sleep recordings, one recording with dopaminergic treatment, and one recording with adaptive servoventilation.
The PLMs were temporally dissociated from cortical arousals as well as from respiratory or heart rate events. PLMs were suppressed by pramipexole and persisted after treatment of apnea.
The disconnection of PLMs from arousals supports a spinal generator or peripheral trigger mechanism for PLMs. The suppression of movements by a dopamine agonist suggests that its site of action is caudal to the cervical lesion and outside of the brain. Our observation provides significant new knowledge about the pathogenesis of PLMs and warrants studies in larger populations.
Salminen AV; Manconi M; Rimpilä V; Luoto TM; Koskinen E; Ferri R; Öhman J; Polo O. Disconnection between periodic leg movements and cortical arousals in spinal cord injury. J Clin Sleep Med 2013;9(11):1207-1209.
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