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Volume 10 No. 01
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Scientific Investigations

The Effects of Poor Sleep Quality on Cognitive Function of Patients with Cirrhosis

http://dx.doi.org/10.5664/jcsm.3350

Charmaine A. Stewart, M.D.1; Robert Auger, M.D., F.A.A.S.M.3; Felicity T. B. Enders, Ph.D.2; Donna Felmlee-Devine, M.A.3; Glenn E. Smith, Ph.D.3
1Division of Gastroenterology and Hepatology, Department of Internal Medicine University of Illinois at Chicago, Chicago, IL; 2Division of Biostatistics, Department of Health Sciences Research; 3Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN

Objectives:

This study was conducted to assess the ill-defined relationship between sleep quality and multiple, specific domains of cognitive function in patients with cirrhosis.

Methods:

A comprehensive battery of neuropsychological tests (divided into six neurocognitive domains) and a standardized, validated measure of sleep quality (Pittsburgh Sleep Quality Index [PSQI]) were administered to patients with cirrhosis and without evidence of overt hepatic encephalopathy, recruited from liver transplant and advanced liver disease clinics (n = 34). An inflammatory bowel disease (IBD) control group (n = 23) was similarly recruited and evaluated to control for the secondary effect of a chronic illness on cognition. PSQI global and component scores were used to predict cognitive function in each neurocognitive domain, using linear regression

Results:

Global PSQI scores were significantly higher (indicating poorer sleep quality) in the cirrhosis group (median [range] = 10 [1-19]) than in IBD controls = 5 (1-14); p = 0.002). After controlling for age and education, short duration of sleep was associated with impaired memory for patients with cirrhosis; the use of soporific agents was associated with poor visual-perceptual function in patients with IBD.

Conclusions:

Poor sleep was associated with worsening of the already impaired cognitive function of patients with cirrhosis.

Citation:

Stewart CA; Auger R; Enders FTB; Felmlee-Devine D; Smith GE. The effects of poor sleep quality on cognitive function of patients with cirrhosis. J Clin Sleep Med 2014;10(1):21-26.




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